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PLZF-expressing CD4 T cells show the characteristics of terminally differentiated effector memory CD4 T cells in humans.
Kim, Yeung-Hyen; Zhu, Lingqiao; Pyaram, Kalyani; Lopez, Cesar; Ohye, Richard G; Garcia, J Victor; Green, Glenn E; Chang, Cheong-Hee.
Afiliação
  • Kim YH; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Zhu L; Department of New Business Development, Medytox R&D center, Medytox, Suwon, Korea.
  • Pyaram K; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Lopez C; Shanghai Mabgeek Biotech, Shanghai, P. R. China.
  • Ohye RG; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Garcia JV; Division of Infectious, Disease, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, USA.
  • Green GE; Department of Cardiac Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Chang CH; Division of Infectious, Disease, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, USA.
Eur J Immunol ; 48(7): 1255-1257, 2018 07.
Article em En | MEDLINE | ID: mdl-29572809
We show the presence of lymphoid tissue-resident PLZF+ CD45RA+ RO+ CD4 T cells in humans. They express HLA-DR, granzyme B, and perforin and are low on CCR7 like terminally differentiated effector memory (Temra) cells and are likely generated from effector T cells (Te) or from central (Tcm) or effector (Tem) memory T (Tcm) cells during immune responses. Tn, Naïve T cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Subpopulações de Linfócitos T / Proteína com Dedos de Zinco da Leucemia Promielocítica / Genótipo / Tecido Linfoide Limite: Humans Idioma: En Revista: Eur J Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Subpopulações de Linfócitos T / Proteína com Dedos de Zinco da Leucemia Promielocítica / Genótipo / Tecido Linfoide Limite: Humans Idioma: En Revista: Eur J Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos