Your browser doesn't support javascript.
loading
Matrix Metalloproteinase 1 as a Novel Biomarker for Monitoring Hepatocellular Carcinoma in Liver Transplant Patients.
Sánchez-Lorencio, M I; Saenz, L; Ramirez, P; Villalba-López, F; de la Orden, V; Mediero-Valeros, B; Revilla Nuin, B; Gonzalez, M R; Cascales-Campos, P A; Ferreras-Martínez, D; Noguera-Velasco, J A; Díaz-Rubio, E; Parrilla, P.
Afiliação
  • Sánchez-Lorencio MI; Clinical Analysis Department, Hospital Clínico Universitario Virgen de la Arrixaca-IMIB, Murcia, Spain.
  • Saenz L; Clinical Analysis Department, Complejo Hospitalario de Navarra, Pamplona, Spain. Electronic address: txito3@hotmail.com.
  • Ramirez P; Liver Transplant Unit, Department of Surgery, Hospital Clínico Universitario Virgen de la Arrixaca-IMIB, Murcia, Spain.
  • Villalba-López F; Clinical Analysis Department, Hospital Clínico Universitario Virgen de la Arrixaca-IMIB, Murcia, Spain.
  • de la Orden V; CTC Unit, Molecular Oncology Laboratory, Hospital Clínico Universitario San Carlos, Instituto de Investigación Sanitaria San Carlos, CIBERONC Instituto de Salud Carlos III, Madrid, Spain.
  • Mediero-Valeros B; CTC Unit, Medical Oncology Department, Hospital Clínico San Carlos, Madrid, Spain.
  • Revilla Nuin B; Plataforma de Genómica IMIB-Arrixaca, Murcia, Spain.
  • Gonzalez MR; Liver Transplant Unit, Department of Surgery, Hospital Clínico Universitario Virgen de la Arrixaca-IMIB, Murcia, Spain.
  • Cascales-Campos PA; Liver Transplant Unit, Department of Surgery, Hospital Clínico Universitario Virgen de la Arrixaca-IMIB, Murcia, Spain.
  • Ferreras-Martínez D; Liver Transplant Unit, Department of Surgery, Hospital Clínico Universitario Virgen de la Arrixaca-IMIB, Murcia, Spain.
  • Noguera-Velasco JA; Clinical Analysis Department, Hospital Clínico Universitario Virgen de la Arrixaca-IMIB, Murcia, Spain.
  • Díaz-Rubio E; Medical Oncology Department, Hospital Clínico San Carlos, Madrid, Spain.
  • Parrilla P; Liver Transplant Unit, Department of Surgery, Hospital Clínico Universitario Virgen de la Arrixaca-IMIB, Murcia, Spain.
Transplant Proc ; 50(2): 623-627, 2018 Mar.
Article em En | MEDLINE | ID: mdl-29579870
INTRODUCTION: Orthotopic liver transplantation (LT) is considered to be one of the few curative treatments available for early stages of hepatocellular carcinoma (HCC). Alfa-fetoprotein (AFP) is the most-used biomarker for HCC despite low sensitivity and specificity. Matrix metalloproteinase 1 (MMP-1) has been considered to be involved in the process of vascular invasion of the malignant cells. The objective of this study was to assess the use of MMP-1 for the management of HCC patients for LT. METHODS: Levels in serum of MMP-1 (ng/mL) and AFP (ng/mL) were assessed in 20 HCC patients (Milan criteria) before and 1, 6, and 12 months after LT. RESULTS: There was a strong significant correlation between levels of MMP-1 and levels of AFP (ρ = .954; P ≤ .05). There were statistical differences in the levels of MMP-1 and APF between the pre-transplantation and post-transplantation groups (1 and 12 months). Increments of both markers 6 months after LT compared with the levels 1 month after LT were detected in 4 of the 20 HCC patients. The detection of recurrence by means of imaging was coincident with the increment of both markers 6 months after LT in 3 of those 4 patients. CONCLUSIONS: After 12 months of follow-up, levels of MMP-1 were comparable to AFP levels after LT. Levels of both markers increase 6 months after LT in patients showing recurrence, indicating discriminatory power to predict relapse and thus serving as valuable markers for HCC monitoring. MMP-1 could be useful in the management of HCC after LT.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Transplante de Fígado / Carcinoma Hepatocelular / Metaloproteinase 1 da Matriz / Neoplasias Hepáticas / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Transplante de Fígado / Carcinoma Hepatocelular / Metaloproteinase 1 da Matriz / Neoplasias Hepáticas / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Espanha