Identification of the RNA Pseudoknot within the 3' End of the Porcine Reproductive and Respiratory Syndrome Virus Genome as a Pathogen-Associated Molecular Pattern To Activate Antiviral Signaling via RIG-I and Toll-Like Receptor 3.

Xie, Sha; Chen, Xin-Xin; Qiao, Songlin; Li, Rui; Sun, Yangang; Xia, Shuangfei; Wang, Lin-Jian; Luo, Xuegang; Deng, Ruiguang; Zhou, En-Min; Zhang, Gai-Ping

Xie, Sha; Chen, Xin-Xin; Qiao, Songlin; Li, Rui; Sun, Yangang; Xia, Shuangfei; Wang, Lin-Jian; Luo, Xuegang; Deng, Ruiguang; Zhou, En-Min; Zhang, Gai-Ping.

Afiliação

Xie S; College of Veterinary Medicine, Northwest A&F University, Yangling, People's Republic of China.
Chen XX; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, China.
Qiao S; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, China.
Li R; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, China.
Sun Y; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, China.
Xia S; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, China.
Wang LJ; College of Veterinary Medicine, Jilin University, Changchun, China.
Luo X; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, People's Republic of China.
Deng R; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, China.
Zhou EM; College of Veterinary Medicine, Northwest A&F University, Yangling, People's Republic of China.
Zhang GP; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, China.

J Virol ; 92(12)2018 06 15.

Article em En | MEDLINE | ID: mdl-29618647

Assuntos

Proteína DEAD-box 58/genética; Moléculas com Motivos Associados a Patógenos/imunologia; Vírus da Síndrome Respiratória e Reprodutiva Suína/genética; Dobramento de RNA/genética; Receptor 3 Toll-Like/genética; Regiões 3' não Traduzidas/genética; Animais; Linhagem Celular; Chlorocebus aethiops; Genoma Viral/genética; Helicase IFIH1 Induzida por Interferon/genética; Interferon-alfa/imunologia; Interferon beta/imunologia; Sequências Repetidas Invertidas/genética; Moléculas com Motivos Associados a Patógenos/metabolismo; Síndrome Respiratória e Reprodutiva Suína/imunologia; Síndrome Respiratória e Reprodutiva Suína/virologia; Vírus da Síndrome Respiratória e Reprodutiva Suína/imunologia; Interferência de RNA; RNA Interferente Pequeno/genética; Sus scrofa; Suínos; Doenças dos Suínos/virologia; Receptor 7 Toll-Like/genética

Palavras-chave

IFN; PAMPs; PRRSV; PRRs; pseudoknot

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Síndrome Respiratória e Reprodutiva Suína / Receptor 3 Toll-Like / Dobramento de RNA / Moléculas com Motivos Associados a Patógenos / Proteína DEAD-box 58 Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Virol Ano de publicação: 2018 Tipo de documento: Article

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