Popolohuanones G - I, Dimeric Sesquiterpene Quinones with IL-6 Inhibitory Activity from the Marine Sponge Dactylospongia elegans.
Chem Biodivers
; 15(6): e1800078, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29635790
ABSTRACT
Chemical investigation of the marine sponge Dactylospongia elegans, collected from the South China Sea, afforded three new dimeric sesquiterpene quinones, popolohuanones G - I (1 - 3), together with two known analogs, popolohuanones B (4) and C (5). The new structures were determined by HR-ESI-MS and 1D- and 2D-NMR analyses. All the five compounds showed no cytotoxic activity against five human cancer cell lines, while popolohuanone H (2) showed potent inhibitory activity against IL-6, an inflammatory cytokine, at the concentration of 10 µm.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Quinonas
/
Sesquiterpenos
/
Interleucina-6
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Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Biodivers
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2018
Tipo de documento:
Article