Acquisition of N-Glycosylation Sites in Immunoglobulin Heavy Chain Genes During Local Expansion in Parotid Salivary Glands of Primary Sjögren Patients.

Visser, Annie; Doorenspleet, Marieke E; de Vries, Niek; Spijkervet, Fred K L; Vissink, Arjan; Bende, Richard J; Bootsma, Hendrika; Kroese, Frans G M; Bos, Nicolaas A

Visser, Annie; Doorenspleet, Marieke E; de Vries, Niek; Spijkervet, Fred K L; Vissink, Arjan; Bende, Richard J; Bootsma, Hendrika; Kroese, Frans G M; Bos, Nicolaas A.

Afiliação

Visser A; Department of Rheumatology and Clinical Immunology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands.
Doorenspleet ME; Department of Clinical Immunology and Rheumatology, Academic Medical Center and University of Amsterdam, Amsterdam, Netherlands.
de Vries N; Rheumatology and Immunology Center, Academic Medical Center, Amsterdam, Netherlands.
Spijkervet FKL; Laboratory for Genome Analysis, Academic Medical Center, Amsterdam, Netherlands.
Vissink A; Department of Clinical Immunology and Rheumatology, Academic Medical Center and University of Amsterdam, Amsterdam, Netherlands.
Bende RJ; Rheumatology and Immunology Center, Academic Medical Center, Amsterdam, Netherlands.
Bootsma H; Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Center Groningen, Groningen, Netherlands.
Kroese FGM; Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Center Groningen, Groningen, Netherlands.
Bos NA; Department of Pathology, Academic Medical Center and University of Amsterdam, Amsterdam, Netherlands.

Front Immunol ; 9: 491, 2018.

Article em En | MEDLINE | ID: mdl-29662487

Assuntos

Linfócitos B/imunologia; Cadeias Pesadas de Imunoglobulinas/genética; Glândula Parótida/fisiologia; RNA/genética; Glândulas Salivares/fisiologia; Síndrome de Sjogren/imunologia; Adolescente; Adulto; Idoso; Idoso de 80 Anos ou mais; Proliferação de Células; Seleção Clonal Mediada por Antígeno; Células Clonais; Glicosilação; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Cadeias Pesadas de Imunoglobulinas/metabolismo; Lectinas/imunologia; Ativação Linfocitária; Pessoa de Meia-Idade; Adulto Jovem

Palavras-chave

B-cell; N-glycosylation; Sjögren syndrome; heavy chain; next generation sequencing; parotid Gland

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glândula Parótida / Glândulas Salivares / RNA / Linfócitos B / Síndrome de Sjogren / Cadeias Pesadas de Imunoglobulinas Limite: Adolescent / Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Front Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda

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