Affinity-Driven Covalent Modulator of the Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Cascade.

Chern, Jeffy; Lu, Chun-Ping; Fang, Zhanxiong; Chang, Ching-Ming; Hua, Kuo-Feng; Chen, Yi-Ting; Ng, Cheng Yang; Chen, Yi-Lin Sophia; Lam, Yulin; Wu, Shih-Hsiung

Chern, Jeffy; Lu, Chun-Ping; Fang, Zhanxiong; Chang, Ching-Ming; Hua, Kuo-Feng; Chen, Yi-Ting; Ng, Cheng Yang; Chen, Yi-Lin Sophia; Lam, Yulin; Wu, Shih-Hsiung.

Afiliação

Chern J; Institute of Biological Chemistry, Academia Sinica, Taiwan.
Lu CP; Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan.
Fang Z; Department of Chemistry, National Taiwan University, Taipei, Taiwan.
Chang CM; Department of Food Science, Fu Jen Catholic University, Taipei, Taiwan.
Hua KF; Department of Chemistry, National University of Singapore, Singapore.
Chen YT; Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan.
Ng CY; Department of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Chen YS; Department of Chemistry, National Taiwan University, Taipei, Taiwan.
Lam Y; Department of Chemistry, National University of Singapore, Singapore.
Wu SH; Department of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.

Angew Chem Int Ed Engl ; 57(24): 7040-7045, 2018 06 11.

Article em En | MEDLINE | ID: mdl-29664161

Assuntos

4-Butirolactona/análogos & derivados; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Benzodioxóis/farmacologia; Gliceraldeído-3-Fosfato Desidrogenases/metabolismo; 4-Butirolactona/farmacologia; Animais; Linhagem Celular Tumoral; Resistencia a Medicamentos Antineoplásicos; Humanos; Camundongos; Modelos Moleculares; Neoplasias/tratamento farmacológico; Neoplasias/metabolismo; Transdução de Sinais/efeitos dos fármacos; Espectrometria de Massas em Tandem

Palavras-chave

asymmetric synthesis; castration-resistant prostate cancer; covalent inhibitors; enzymes; multiple-drug resistance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: 4-Butirolactona / Apoptose / Benzodioxóis / Gliceraldeído-3-Fosfato Desidrogenases / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Taiwan

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