Human alveolar macrophages predominately express combined classical M1 and M2 surface markers in steady state.
Respir Res
; 19(1): 66, 2018 04 18.
Article
em En
| MEDLINE
| ID: mdl-29669565
ABSTRACT
Alveolar macrophages (AM) are critical to the homeostasis of the inflammatory environment in the lung. Differential expression of surface markers classifies macrophages to either classically (M1) or alternatively activated (M2). We investigated the phenotype of human alveolar macrophages (AM) in adults living in two different geographical locations UK and Malawi. We show that the majority of AM express high levels of M1 and M2 markers simultaneously, with the M1/M2 phenotype being stable in individuals from different geographical locations. The combined M1/M2 features confer to AM a hybrid phenotype, which does not fit the classic macrophage classification. This hybrid phenotype may confer to alveolar macrophages an ability to quickly switch between M1 or M2 associated functions allowing for appropriate responses to stimuli and tissue environment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenótipo
/
Antígenos CD
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Macrófagos Alveolares
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Ativação de Macrófagos
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Humans
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Respir Res
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Reino Unido