Structural characterization and immunosuppressive activity of a new pregnane glycoside from Epigynum cochinchinensis.
Nat Prod Res
; 33(22): 3210-3214, 2019 Nov.
Article
em En
| MEDLINE
| ID: mdl-29726713
ABSTRACT
Phytochemical investigation on the ethyl acetate fraction of the leaves of Epigynum cochinchinensis led to the isolation of a new C21 pregnane glycoside, epigycoside B (1), together with three known analogues. Their structures were elucidated on the basis of extensive spectroscopic techniques, including UV, MS, and NMR experiments, as well as the chemical methods. Compound 1 displayed in vitro immunosuppressive activity against concanavalin A (Con A)/Lipopolysaccharides (LPS)-stimulated proliferation of mice splenocyte. The activity was significant as compared with control group at 50 µM concentration.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pregnanos
/
Apocynaceae
/
Glicosídeos
/
Imunossupressores
Limite:
Animals
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2019
Tipo de documento:
Article