Spliceosome Profiling Visualizes Operations of a Dynamic RNP at Nucleotide Resolution.

Burke, Jordan E; Longhurst, Adam D; Merkurjev, Daria; Sales-Lee, Jade; Rao, Beiduo; Moresco, James J; Yates, John R; Li, Jingyi Jessica; Madhani, Hiten D

Burke, Jordan E; Longhurst, Adam D; Merkurjev, Daria; Sales-Lee, Jade; Rao, Beiduo; Moresco, James J; Yates, John R; Li, Jingyi Jessica; Madhani, Hiten D.

Afiliação

Burke JE; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Longhurst AD; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Merkurjev D; Department of Statistics, University of California, Los Angeles, Los Angeles, CA, USA.
Sales-Lee J; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Rao B; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Moresco JJ; Department of Molecular Medicine, the Scripps Research Institute, La Jolla, CA, USA.
Yates JR; Department of Molecular Medicine, the Scripps Research Institute, La Jolla, CA, USA.
Li JJ; Department of Statistics, University of California, Los Angeles, Los Angeles, CA, USA.
Madhani HD; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address: hitenmadhani@gmail.com.

Cell ; 173(4): 1014-1030.e17, 2018 05 03.

Article em En | MEDLINE | ID: mdl-29727661

Assuntos

Ribonucleoproteínas Nucleares Pequenas/metabolismo; Proteínas de Saccharomyces cerevisiae/metabolismo; Spliceossomos/metabolismo; Trifosfato de Adenosina/metabolismo; Teorema de Bayes; RNA Helicases DEAD-box/genética; RNA Helicases DEAD-box/metabolismo; Imunoprecipitação; Precursores de RNA/metabolismo; Splicing de RNA; Fatores de Processamento de RNA/genética; Fatores de Processamento de RNA/metabolismo; RNA Fúngico/metabolismo; Saccharomyces cerevisiae/metabolismo; Proteínas de Saccharomyces cerevisiae/genética; Telomerase/genética; Telomerase/metabolismo; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo

Palavras-chave

pre-mRNA splicing; spliceosome; splicing catalysis; splicing fidelity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Spliceossomos / Ribonucleoproteínas Nucleares Pequenas / Proteínas de Saccharomyces cerevisiae Tipo de estudo: Prognostic_studies Idioma: En Revista: Cell Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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