Your browser doesn't support javascript.
loading
Eukaryotic cell survival mechanisms: Disease relevance and therapeutic intervention.
Twayana, Krishna Sundar; Ravanan, Palaniyandi.
Afiliação
  • Twayana KS; Apoptosis and Cell Survival Research Laboratory, Department of Biosciences, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu-632014, India.
  • Ravanan P; Apoptosis and Cell Survival Research Laboratory, Department of Biosciences, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu-632014, India. Electronic address: ravanan.p@vit.ac.in.
Life Sci ; 205: 73-90, 2018 Jul 15.
Article em En | MEDLINE | ID: mdl-29730169
Cell responds to stress by activating various modes of stress responses which aim for minimal damage to cells and speedy recovery from the insults. However, unresolved stresses exceeding the tolerance limit lead to cell death (apoptosis, autophagy etc.) that helps to get rid of damaged cells and protect cell integrity. Furthermore, aberrant stress responses are the hallmarks of several pathophysiologies (neurodegeneration, metabolic diseases, cancer etc.). The catastrophic remodulation of stress responses is observed in cancer cells in favor of their uncontrolled growth. Whereas pro-survival stress responses redirected to death signaling provokes excessive cell death in neurodegeneration. Clear understanding of such mechanistic link to disease progression is required in order to modulate these processes for new therapeutic targets. The current review explains this with respect to novel drug discoveries and other breakthroughs in therapeutics.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Eucarióticas / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Life Sci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Índia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Eucarióticas / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Life Sci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Índia