Acquired low cholesterol: diagnosis and relevance to safety of low LDL therapeutic targets.
Curr Opin Lipidol
; 29(4): 318-326, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29746303
ABSTRACT
PURPOSE OF REVIEW Acquired hypocholesterolaemia occurs more commonly than inherited hypocholesterolaemia but has received little attention in the literature. In this review, we discuss the causes and underlying mechanisms of acquired hypocholesterolaemia and its relevance to safety of therapeutically induced decreased LDL cholesterol levels. RECENT FINDINGS:
Hypocholesterolaemia is increasingly identified as cholesterol testing becomes more widespread in the assessment of cardiovascular risk. Lower therapeutic targets for LDL cholesterol are also being achieved more regularly with the introduction of more intensive cholesterol-lowering regimens. Acquired hypocholesterolaemia may be the presenting feature of treatable diseases. Understanding its mechanisms may also provide new treatment approaches for neoplastic disease, such as breast cancer, and infections, such as tuberculosis.SUMMARY:
When hypocholesterolaemia is discovered, it is important to identify its cause. Further research into the pathogenesis of hypocholesterolaemia may provide new therapies for primary diseases underlying it.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Segurança
/
Terapia de Alvo Molecular
/
Hipercolesterolemia
/
LDL-Colesterol
/
Anticolesterolemiantes
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Lipidol
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2018
Tipo de documento:
Article