The association between serum vitamin d level and cognitive function in older adults: Cooper Center Longitudinal Study.
Prev Med
; 113: 57-61, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29753804
ABSTRACT
Low blood level of vitamin D and low physical activity have been linked to the development of cognitive impairment in older adults. The purpose of the present study was to examine the relationship between serum vitamin D and cognition as measured via the Montreal Cognitive Assessment (MoCA) in a healthy, older population. The study sample consisted of 4358 patients from the Cooper Clinic in Dallas, TX. All participants underwent a maximal graded exercise test to determine cardiorespiratory fitness (CRF). Cognitive impairment was defined as a MoCA score <25. Low vitamin D status was defined as serum 25-hydroxyvitamin D <30â¯ng/mL. Multivariable logistic regression analysis was employed to evaluate the association between vitamin D blood level and MoCA score. A low MoCA score was directly associated with higher age (OR 1.75, 95% CI 1.53, 1.99), and inversely associated with female sex (OR 0.63, 95% CI 0.51, 0.77), and years of education (OR 0.87, 95% CI 0.84, 0.91). When controlling for significant predictors (age, sex, and education), the low vitamin D group had a significantly greater likelihood of having a low MoCA score (OR 1.26, 95% CI 1.04, 1.51). The vitamin D effect remained significant when CRF was added to the model (OR 1.23, 95% CI 1.02, 1.48). In conclusion, low vitamin D was shown to be associated with cognitive impairment. Therefore, preventive measures such as vitamin D supplementation may play a protective role in memory loss and/or age-associated cognitive decline.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Cognição
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Testes de Estado Mental e Demência
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Prognostic_studies
Limite:
Female
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Humans
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Male
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Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Prev Med
Ano de publicação:
2018
Tipo de documento:
Article