[Effects decomposition in mediation analysis: a numerical example]. / Scomposizione degli effetti nell'analisi di mediazione: un esempio numerico.
Epidemiol Prev
; 42(2): 127-133, 2018.
Article
em It
| MEDLINE
| ID: mdl-29774709
ABSTRACT
Mediation analysis aims to decompose the total effect of the exposure on the outcome into a direct effect (unmediated) and an indirect effect (mediated by a mediator). When the interest also lies on understanding whether the exposure effect differs in different sub-groups of study population or under different scenarios, the mediation analysis needs to be integrated with interaction analysis. In this setting it is necessary to decompose the total effect not only into two components, the direct and indirect effects, but other two components linked to interaction. The interaction between the exposure and the mediator in their effect on the outcome could indeed act through the effect of the exposure on the mediator or through the mediator when the mediator is not totally explained by the exposure. We describe options for decomposition, proposed in literature, of the total effect and we illustrate them through a hypothetical example of the effect of age at diagnosis of cancer on survival, mediated and unmediated by the therapeutical approach, and a numerical example.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Modelos Estatísticos
/
Exposição Ambiental
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
It
Revista:
Epidemiol Prev
Assunto da revista:
EPIDEMIOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article