The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.

Koren, Itay; Timms, Richard T; Kula, Tomasz; Xu, Qikai; Li, Mamie Z; Elledge, Stephen J

The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.

Koren, Itay; Timms, Richard T; Kula, Tomasz; Xu, Qikai; Li, Mamie Z; Elledge, Stephen J.

Afiliação

Koren I; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Timms RT; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Kula T; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Xu Q; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Li MZ; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Elledge SJ; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: selledge@genetics.med.harvard.edu.

Cell ; 173(7): 1622-1635.e14, 2018 06 14.

Article em En | MEDLINE | ID: mdl-29779948

Assuntos

Proteoma/metabolismo; Ubiquitina-Proteína Ligases/metabolismo; Motivos de Aminoácidos; Animais; Antígenos de Neoplasias/metabolismo; Sistemas CRISPR-Cas/genética; Biologia Computacional/métodos; Vetores Genéticos/genética; Vetores Genéticos/metabolismo; Células HEK293; Humanos; Lentivirus/genética; Leupeptinas/farmacologia; Fases de Leitura Aberta/genética; Peptídeos/metabolismo; Complexo de Endopeptidases do Proteassoma/química; Complexo de Endopeptidases do Proteassoma/metabolismo; Estabilidade Proteica/efeitos dos fármacos; Subunidades Proteicas/metabolismo; Proteólise; Proteoma/genética; Receptores de Citocinas/genética; Receptores de Citocinas/metabolismo

Palavras-chave

C terminus; CRL; Cullin; DesCEND; E3 ubiquitin ligase; GPS; degron; global protein stability; protein degradation; ubiquitination

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteoma / Ubiquitina-Proteína Ligases Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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