Involvement of the CB<sub>2</sub> cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma.

Khan, Mohammed I; Sobocinska, Anna A; Brodaczewska, Klaudia K; Zielniok, Katarzyna; Gajewska, Malgorzata; Kieda, Claudine; Czarnecka, Anna M; Szczylik, Cezary

Involvement of the CB₂ cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma.

Khan, Mohammed I; Sobocinska, Anna A; Brodaczewska, Klaudia K; Zielniok, Katarzyna; Gajewska, Malgorzata; Kieda, Claudine; Czarnecka, Anna M; Szczylik, Cezary.

Afiliação

Khan MI; Molecular Oncology Laboratory, Department of Oncology, Military Institute of Medicine, ul. Szaserów 128, 04-141, Warsaw, Poland. imrankhanbioinfo@gmail.com.
Sobocinska AA; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, N6A 3K7, Canada. imrankhanbioinfo@gmail.com.
Brodaczewska KK; Molecular Oncology Laboratory, Department of Oncology, Military Institute of Medicine, ul. Szaserów 128, 04-141, Warsaw, Poland.
Zielniok K; Faculty of Biology, Warsaw University, ul. Miecznikowa 1, 02-096, Warsaw, Poland.
Gajewska M; Molecular Oncology Laboratory, Department of Oncology, Military Institute of Medicine, ul. Szaserów 128, 04-141, Warsaw, Poland.
Kieda C; Department of Physiological Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776, Warsaw, Poland.
Czarnecka AM; Department of Physiological Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776, Warsaw, Poland.
Szczylik C; Molecular Oncology Laboratory, Department of Oncology, Military Institute of Medicine, ul. Szaserów 128, 04-141, Warsaw, Poland.

BMC Cancer ; 18(1): 583, 2018 May 23.

Article em En | MEDLINE | ID: mdl-29792186

Assuntos

Benzoxazinas/farmacologia; Agonistas de Receptores de Canabinoides/farmacologia; Carcinoma de Células Renais/tratamento farmacológico; Neoplasias Renais/tratamento farmacológico; Morfolinas/farmacologia; Naftalenos/farmacologia; Receptor CB2 de Canabinoide/metabolismo; Apoptose/efeitos dos fármacos; Benzoxazinas/uso terapêutico; Agonistas de Receptores de Canabinoides/uso terapêutico; Antagonistas de Receptores de Canabinoides/farmacologia; Carcinoma de Células Renais/patologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Pontos de Checagem da Fase G1 do Ciclo Celular/efeitos dos fármacos; Humanos; Neoplasias Renais/patologia; Morfolinas/uso terapêutico; Naftalenos/uso terapêutico; Receptor CB1 de Canabinoide/agonistas; Receptor CB1 de Canabinoide/antagonistas & inibidores; Receptor CB1 de Canabinoide/metabolismo; Receptor CB2 de Canabinoide/agonistas; Receptor CB2 de Canabinoide/antagonistas & inibidores; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

CB1 and CB2 receptors; Endocannabinoid system (ECS); JWH-133; Renal cell carcinoma; WIN 55,2122 mesylate

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Morfolinas / Receptor CB2 de Canabinoide / Benzoxazinas / Agonistas de Receptores de Canabinoides / Neoplasias Renais / Naftalenos Limite: Humans Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Polônia

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