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An Investigation into the Prediction of the Plasma Concentration-Time Profile and Its Interindividual Variability for a Range of Flavin-Containing Monooxygenase Substrates Using a Physiologically Based Pharmacokinetic Modeling Approach.
Reddy, Venkatesh Pilla; Jones, Barry C; Colclough, Nicola; Srivastava, Abhishek; Wilson, Joanne; Li, Danxi.
Afiliação
  • Reddy VP; Departments of Modelling and Simulation, Oncology Drug Metabolism and Pharmacokinetics (V.P.R.), Departments of Drug Metabolism and Pharmacokinetics and Oncology (B.C.J., N.C., J.W.), and Department of Drug Safety and Metabolism (A.S.), IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom; and
  • Jones BC; Departments of Modelling and Simulation, Oncology Drug Metabolism and Pharmacokinetics (V.P.R.), Departments of Drug Metabolism and Pharmacokinetics and Oncology (B.C.J., N.C., J.W.), and Department of Drug Safety and Metabolism (A.S.), IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom; and
  • Colclough N; Departments of Modelling and Simulation, Oncology Drug Metabolism and Pharmacokinetics (V.P.R.), Departments of Drug Metabolism and Pharmacokinetics and Oncology (B.C.J., N.C., J.W.), and Department of Drug Safety and Metabolism (A.S.), IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom; and
  • Srivastava A; Departments of Modelling and Simulation, Oncology Drug Metabolism and Pharmacokinetics (V.P.R.), Departments of Drug Metabolism and Pharmacokinetics and Oncology (B.C.J., N.C., J.W.), and Department of Drug Safety and Metabolism (A.S.), IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom; and
  • Wilson J; Departments of Modelling and Simulation, Oncology Drug Metabolism and Pharmacokinetics (V.P.R.), Departments of Drug Metabolism and Pharmacokinetics and Oncology (B.C.J., N.C., J.W.), and Department of Drug Safety and Metabolism (A.S.), IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom; and
  • Li D; Departments of Modelling and Simulation, Oncology Drug Metabolism and Pharmacokinetics (V.P.R.), Departments of Drug Metabolism and Pharmacokinetics and Oncology (B.C.J., N.C., J.W.), and Department of Drug Safety and Metabolism (A.S.), IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom; and
Drug Metab Dispos ; 46(9): 1259-1267, 2018 Sep.
Article em En | MEDLINE | ID: mdl-29895591
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigenases / Taxa de Depuração Metabólica / Hepatócitos / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigenases / Taxa de Depuração Metabólica / Hepatócitos / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article