[EPIGENETIC REGULATION OF ADRENAL CHROMAFFIN CELLS DEVELOPMENT (REVIEW)].

Obernikhin, S; Yaglova, N; Tsomartova, D; Torbek, V; Ivanova, M

Obernikhin, S; Yaglova, N; Tsomartova, D; Torbek, V; Ivanova, M.

Afiliação

Obernikhin S; 1Federal State Budgetary Institution Research Institute of Human Morphology, Moscow; 2Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, Russia.
Yaglova N; 1Federal State Budgetary Institution Research Institute of Human Morphology, Moscow; 2Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, Russia.
Tsomartova D; 1Federal State Budgetary Institution Research Institute of Human Morphology, Moscow; 2Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, Russia.
Torbek V; 1Federal State Budgetary Institution Research Institute of Human Morphology, Moscow; 2Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, Russia.
Ivanova M; 1Federal State Budgetary Institution Research Institute of Human Morphology, Moscow; 2Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, Russia.

Georgian Med News ; (278): 138-146, 2018 May.

Article em Ru | MEDLINE | ID: mdl-29905560

ABSTRACT

ABSTRACT

Chromaffin cells of adrenal medulla have traditionally been considered as modified sympathetic neurons. However, the results of recent studies indicate the need to revise this concept. The article reviews recent findings in origin and ontogeny of adrenal chromaffin cells and transcriptional and posttranscriptional regulation of developmental processes. The article summarizes data on transcriptional control of chromaffin cells proliferation and maturation and participation of microRNA in regulation of chromaffin and sympathetic neuronal phenotype gene expression.

Assuntos

Medula Suprarrenal/metabolismo; Células Cromafins/metabolismo; Epigênese Genética; Regulação da Expressão Gênica no Desenvolvimento; Medula Suprarrenal/citologia; Medula Suprarrenal/crescimento & desenvolvimento; Animais; Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética; Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo; Diferenciação Celular; Proliferação de Células; Células Cromafins/citologia; Proteínas de Homeodomínio/genética; Proteínas de Homeodomínio/metabolismo; Humanos; MicroRNAs/genética; MicroRNAs/metabolismo; Neurônios/citologia; Neurônios/metabolismo; Proteínas Repressoras/genética; Proteínas Repressoras/metabolismo; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo; Transcrição Gênica

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Suprarrenal / Regulação da Expressão Gênica no Desenvolvimento / Células Cromafins / Epigênese Genética Limite: Animals / Humans Idioma: Ru Revista: Georgian Med News Assunto da revista: MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Federação Russa

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