Neurotropin inhibits neuronal activity through potentiation of sustained Kv currents in primary cultured DRG neurons.
J Pharmacol Sci
; 137(3): 313-316, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29907377
ABSTRACT
Neurotropin (NTP) is a Japanese analgesic agent for treating neuropathic pain; however, its method of action remains unclear. This study examined the effects of NTP on the activity of small dorsal root ganglion (DRG) neurons using whole-cell patch clamp recordings. After 3 days of treatment, NTP decreased current injection-induced firing activity of cultured DRG neurons by raising the current threshold for action potential generation. Additionally, NTP increased the sustained component of voltage-gated potassium (Kv) channel currents without affecting other K+ currents. These results suggest that NTP inhibits the firing activity of DRG neurons through augmentation of sustained Kv current.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Canais de Potássio de Abertura Dependente da Tensão da Membrana
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Gânglios Espinais
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Analgésicos
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
J Pharmacol Sci
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão