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MAGE-A3 immunotherapeutic as adjuvant therapy for patients with resected, MAGE-A3-positive, stage III melanoma (DERMA): a double-blind, randomised, placebo-controlled, phase 3 trial.
Dreno, Brigitte; Thompson, John F; Smithers, Bernard Mark; Santinami, Mario; Jouary, Thomas; Gutzmer, Ralf; Levchenko, Evgeny; Rutkowski, Piotr; Grob, Jean-Jacques; Korovin, Sergii; Drucis, Kamil; Grange, Florent; Machet, Laurent; Hersey, Peter; Krajsova, Ivana; Testori, Alessandro; Conry, Robert; Guillot, Bernard; Kruit, Wim H J; Demidov, Lev; Thompson, John A; Bondarenko, Igor; Jaroszek, Jaroslaw; Puig, Susana; Cinat, Gabriela; Hauschild, Axel; Goeman, Jelle J; van Houwelingen, Hans C; Ulloa-Montoya, Fernando; Callegaro, Andrea; Dizier, Benjamin; Spiessens, Bart; Debois, Muriel; Brichard, Vincent G; Louahed, Jamila; Therasse, Patrick; Debruyne, Channa; Kirkwood, John M.
Afiliação
  • Dreno B; Department of Dermatooncology, Hotel Dieu Nantes University Hospital, Nantes, France.
  • Thompson JF; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
  • Smithers BM; Queensland Melanoma Project, Discipline of Surgery, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
  • Santinami M; Melanoma Sarcoma Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Jouary T; Service d'Oncologie Médicale, Hôpital François Mitterrand, Pau, France.
  • Gutzmer R; Skin Cancer Center Hannover, Department of Dermatology, Hannover Medical School, Hannover, Germany.
  • Levchenko E; Petrov Research Institute of Oncology, St Petersburg, Russia.
  • Rutkowski P; Department of Soft Tissue, Bone Sarcoma, and Melanoma, Maria Sklodowska-Curie Institute, Oncology Center, Warsaw, Poland.
  • Grob JJ; Department of Dermatology and Skin Cancers, La Timone APHM Hospital, Aix-Marseille University, Marseille, France.
  • Korovin S; Department of Skin and Soft Tissue Tumours, National Cancer Institute, Kiev, Ukraine.
  • Drucis K; Swissmed Centrum Zdrowia, Gdansk, Poland; Department of Surgical Oncology, Gdansk Medical University, Gdansk, Poland.
  • Grange F; Dermatology Department, Hôpital Robert Debré, Université de Reims Champagne-Ardenne, Reims, France.
  • Machet L; Department of Dermatology, Centre Hospitalier Universitaire, Tours, France; UFR de Médecine, Université François-Rabelais, Tours, France.
  • Hersey P; Melanoma Immunology and Oncology Group, Centenary Institute, University of Sydney, Sydney, NSW, Australia; Melanoma Institute Australia, Sydney, NSW, Australia.
  • Krajsova I; Dermato-oncology Department, General University Hospital, Prague, Czech Republic.
  • Testori A; Columbus Clinic Center, Milan, Italy.
  • Conry R; Division of Hematology & Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Guillot B; Département de Dermatologie, Centre Hospitalier Universitaire, Hôpital Saint-Éloi, Montpellier, France.
  • Kruit WHJ; Department of Medical Oncology, Erasmus MC Cancer institute, Rotterdam, Netherlands.
  • Demidov L; Cancer Research Center, Moscow, Russia.
  • Thompson JA; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia; Seattle Cancer Care Alliance, University of Washington, Seattle, WA, USA.
  • Bondarenko I; Department of Oncology and Medical Radiology, Dnipropetrovsk State Medical Academy, Dnipropetrovsk, Ukraine.
  • Jaroszek J; Centrum Medyczne Bienkowski, Klinika Chirurgii Plastycznej, Bydgoszcz, Poland; Department of Oncological Surgery, Oncology Center, Bydgoszcz, Poland.
  • Puig S; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III, Barcelona, Spain.
  • Cinat G; Instituto de Oncología Ángel H Roffo, Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Hauschild A; Department of Dermatology, Venereology, and Allergology, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Goeman JJ; Medical Statistics, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands.
  • van Houwelingen HC; Medical Statistics, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands.
  • Ulloa-Montoya F; GlaxoSmithKline, Rixensart, Belgium. Electronic address: fernando.x.ulloa-montoya@GSK.com.
  • Callegaro A; GlaxoSmithKline, Rixensart, Belgium.
  • Dizier B; GlaxoSmithKline, Rixensart, Belgium; Immunology Translational Medicine, UCB, Brussels, Belgium.
  • Spiessens B; GlaxoSmithKline, Rixensart, Belgium; Biostatistics Department, Janssen Research & Development, Beerse, Belgium.
  • Debois M; GlaxoSmithKline, Rixensart, Belgium.
  • Brichard VG; GlaxoSmithKline, Rixensart, Belgium; ViaNova Biosciences, Brussels, Belgium.
  • Louahed J; GlaxoSmithKline, Rixensart, Belgium.
  • Therasse P; GlaxoSmithKline, Rixensart, Belgium; Laboratoires Servier, Paris, France.
  • Debruyne C; GlaxoSmithKline, Rixensart, Belgium; University Hospitals Leuven, Leuven, Belgium.
  • Kirkwood JM; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Lancet Oncol ; 19(7): 916-929, 2018 07.
Article em En | MEDLINE | ID: mdl-29908991
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Imunoconjugados / Imunoterapia / Melanoma / Antígenos de Neoplasias / Proteínas de Neoplasias Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Imunoconjugados / Imunoterapia / Melanoma / Antígenos de Neoplasias / Proteínas de Neoplasias Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França