The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats.
Science
; 229(4714): 675-9, 1985 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-2992082
ABSTRACT
Expression of the pX protein of human T-cell leukemia virus type I (HTLV-I) in animal cells demonstrates that this protein is a specific transcriptional activator of the long terminal repeats (LTR) of HTLV-I. Several other promoters are not affected by pX. No lymphocyte-specific factors are required for this activation. pX can be detected in the nucleus of transfected monkey kidney cells (line CV1) by indirect immunofluorescence. These results indicate that the pX protein is essential for the replication cycle of the virus and that it may be directly involved in the immortalization of human lymphocytes by HTLV-I.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas Virais
/
Deltaretrovirus
Idioma:
En
Revista:
Science
Ano de publicação:
1985
Tipo de documento:
Article