A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus.
Science
; 230(4722): 177-9, 1985 Oct 11.
Article
em En
| MEDLINE
| ID: mdl-2994227
ABSTRACT
A new, competitive, nonpeptide cholecystokinin (CCK) antagonist, asperlicin, was isolated from the fungus Aspergillus alliaceus. The compound has 300 to 400 times the affinity for pancreatic, ileal, and gallbladder CCK receptors than proglumide, a standard agent of this class. Moreover, asperlicin is highly selective for peripheral CCK receptors relative to brain CCK and gastrin receptors. Since asperlicin also exhibits long-lasting CCK antagonist activity in vivo, it should provide a valuable tool for investigating the physiological and pharmacological actions of CCK.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aspergillus
/
Benzodiazepinonas
/
Colecistocinina
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1985
Tipo de documento:
Article