BCP/PC mutation prevalence and their association with HBV replication in HIV/HBV co-infected patients.
Arch Virol
; 163(10): 2829-2833, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-29948380
ABSTRACT
The high prevalence (14.3%) of HIV/HBV co-infections reported in west China makes it necessary to screen concurrent HBV infection in HIV carriers. HBV B genotype was shown to be dominant in 54 cases of HIV/HBV co-infection, accounting for 81.48% of the total. The total drug resistance rate observed was 3.70%. A1762T, G1764A and G1896A mutations were common mutations identified in the BCP/PC region. However, the prevalence of the G1896A mutation was significantly high among the HBeAg negative HIV/HBV co-infected patients, and may be associated with high HBV replication. Mutations in the PC region are related to the loss in synthesis of HBeAg and may accelerate HBV replication in HIV positive patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
/
Infecções por HIV
/
Vírus da Hepatite B
/
HIV-1
/
Regiões Promotoras Genéticas
/
Coinfecção
/
Hepatite B
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Arch Virol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China