Low frequency electrical muscle stimulation and endothelial function in advanced heart failure patients.
ESC Heart Fail
; 5(4): 727-731, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29971969
ABSTRACT
AIM:
Obtain initial estimates of the change in brachial artery endothelial function and maximal oxygen uptake (VO2peak ) with 8 weeks of low-frequency electrical muscle stimulation (LF-EMS) or sham in patients with advanced chronic heart failure. METHODS ANDRESULTS:
Using a double blind, randomized design, 35 patients with chronic heart failure (New York Heart Association class III-IV) were assigned to 8 weeks (5 × 60 min per week) of either LF-EMS (4 Hz, continuous) or sham (skin level stimulation only) of the quadriceps and hamstrings muscles. Four of the five sessions were at home and one under supervision. Ultrasound images of resting brachial artery diameter and post 5 min occlusion to determine flow-mediated dilation (FMD), a marker of vascular function and peak oxygen uptake (VO2peak ) during cardiopulmonary exercise test, were measured before and after LF-EMS (n = 20) and sham (n = 15) interventions. FMD improved by 2.56% (95% confidence interval 0.69 to 3.80) with LF-EMS compared with sham (P = 0.07). There were no notable changes in VO2peak .CONCLUSIONS:
Improvements in FMD with LF-EMS may have a clinically meaningful effect as higher FMD is associated with better prognosis. This is a preliminary finding, and a larger trial is warranted.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Volume Sistólico
/
Vasodilatação
/
Endotélio Vascular
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Terapia por Estimulação Elétrica
/
Insuficiência Cardíaca
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
ESC Heart Fail
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Reino Unido