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Upregulation of long noncoding RNA MALAT1 in papillary thyroid cancer and its diagnostic value.
Liu, Jia; Dong, Hanhua; Yang, Yingxu; Qian, Yuejun; Liu, Jianqiu; Li, Zhi; Guan, Hongya; Chen, Zheng; Li, Cuilin; Zhang, Ke; Zhang, Qingsong; Cao, Wei; Lv, Jing.
Afiliação
  • Liu J; Translational Medicine Center, Zhengzhou Central Hospital, Affiliated to Zhengzhou University, Zhengzhou 450007, PR China.
  • Dong H; Translational Medicine Center, Zhengzhou Central Hospital, Affiliated to Zhengzhou University, Zhengzhou 450007, PR China.
  • Yang Y; Translational Medicine Center, Zhengzhou Central Hospital, Affiliated to Zhengzhou University, Zhengzhou 450007, PR China.
  • Qian Y; Translational Medicine Center, Zhengzhou Central Hospital, Affiliated to Zhengzhou University, Zhengzhou 450007, PR China.
  • Liu J; Thyroid surgery, Zhengzhou Central Hospital, Affiliated to Zhengzhou University, Zhengzhou 450007, PR China.
  • Li Z; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, PR China.
  • Guan H; Thyroid surgery, Zhengzhou Central Hospital, Affiliated to Zhengzhou University, Zhengzhou 450007, PR China.
  • Chen Z; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, PR China.
  • Li C; Translational Medicine Center, Zhengzhou Central Hospital, Affiliated to Zhengzhou University, Zhengzhou 450007, PR China.
  • Zhang K; Translational Medicine Center, Zhengzhou Central Hospital, Affiliated to Zhengzhou University, Zhengzhou 450007, PR China.
  • Zhang Q; Thyroid surgery, Zhengzhou Central Hospital, Affiliated to Zhengzhou University, Zhengzhou 450007, PR China.
  • Cao W; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, PR China.
  • Lv J; Thyroid surgery, Zhengzhou Central Hospital, Affiliated to Zhengzhou University, Zhengzhou 450007, PR China.
Future Oncol ; 14(29): 3015-3022, 2018 Dec.
Article em En | MEDLINE | ID: mdl-29987950
AIM: To investigate the expression level of lncRNA MALAT1 in papillary thyroid cancer (PTC) and evaluate its clinical diagnostic value as a biomarker in PTC. METHODS: MALAT1 lncRNA expression in tissues was detected by qRT-PCR. The diagnostic value of MALAT1 as a biomarker in PTC was evaluated with receiver operating characteristics. RESULTS: MALAT1 expression was upregulated in PTC tissues compared with paired corresponding noncancerous tissues. We also found that upregulated MALAT1 expression was correlated with tumor size, lymph node metastases (p = 0.011) and WHO disease stage. The area under the curve was 0.6320, 0.7192, 0.7089 and 0.7000 for PTC, lymph node metastasis, extrathyroidal extension and WHO disease stage prediction, respectively. CONCLUSION: Our finding suggests that MALAT1 may exert oncogenic function in PTC and may be a potential diagnostic marker for this cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / RNA Longo não Codificante / Câncer Papilífero da Tireoide Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Future Oncol Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / RNA Longo não Codificante / Câncer Papilífero da Tireoide Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Future Oncol Ano de publicação: 2018 Tipo de documento: Article