Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function.

Amal, Haitham; Barak, Boaz; Bhat, Vadiraja; Gong, Guanyu; Joughin, Brian A; Wang, Xin; Wishnok, John S; Feng, Guoping; Tannenbaum, Steven R

Amal, Haitham; Barak, Boaz; Bhat, Vadiraja; Gong, Guanyu; Joughin, Brian A; Wang, Xin; Wishnok, John S; Feng, Guoping; Tannenbaum, Steven R.

Afiliação

Amal H; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. haitham.amal85@gmail.com.
Barak B; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Bhat V; Agilent Tech. Inc, Wilmington, DE, 19808, USA.
Gong G; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Joughin BA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Wang X; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Wishnok JS; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Feng G; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Tannenbaum SR; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Mol Psychiatry ; 25(8): 1835-1848, 2020 08.

Article em En | MEDLINE | ID: mdl-29988084

Assuntos

Transtorno do Espectro Autista/genética; Transtorno do Espectro Autista/metabolismo; Proteínas dos Microfilamentos/genética; Mutação; Proteínas do Tecido Nervoso/genética; Proteoma/metabolismo; Sinapses/metabolismo; Animais; Transtorno Autístico/genética; Transtorno Autístico/metabolismo; Modelos Animais de Doenças; Humanos; Camundongos; Proteoma/química

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sinapses / Proteoma / Transtorno do Espectro Autista / Proteínas dos Microfilamentos / Mutação / Proteínas do Tecido Nervoso Limite: Animals / Humans Idioma: En Revista: Mol Psychiatry Assunto da revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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