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A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.
Tsuburaya, Naomi; Homma, Kengo; Higuchi, Tsunehiko; Balia, Andrii; Yamakoshi, Hiroyuki; Shibata, Norio; Nakamura, Seiichi; Nakagawa, Hidehiko; Ikeda, Shin-Ichi; Umezawa, Naoki; Kato, Nobuki; Yokoshima, Satoshi; Shibuya, Masatoshi; Shimonishi, Manabu; Kojima, Hirotatsu; Okabe, Takayoshi; Nagano, Tetsuo; Naguro, Isao; Imamura, Keiko; Inoue, Haruhisa; Fujisawa, Takao; Ichijo, Hidenori.
Afiliação
  • Tsuburaya N; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Homma K; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Higuchi T; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan.
  • Balia A; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya, 466-8555, Japan.
  • Yamakoshi H; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan.
  • Shibata N; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya, 466-8555, Japan.
  • Nakamura S; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan.
  • Nakagawa H; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan.
  • Ikeda SI; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan.
  • Umezawa N; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan.
  • Kato N; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan.
  • Yokoshima S; Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.
  • Shibuya M; Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.
  • Shimonishi M; GCOE Program, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Kojima H; Drug Discovery Initiative (DDI), The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Okabe T; Drug Discovery Initiative (DDI), The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Nagano T; Drug Discovery Initiative (DDI), The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Naguro I; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Imamura K; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.
  • Inoue H; iPSC-based Drug Discovery and Development Team, RIKEN BioResource Center, Kyoto, 606-8507, Japan.
  • Fujisawa T; Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (RIKEN AIP), Kyoto, 606-8507, Japan.
  • Ichijo H; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.
Nat Commun ; 9(1): 2668, 2018 07 10.
Article em En | MEDLINE | ID: mdl-29991716
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Modelos Animais de Doenças / Bibliotecas de Moléculas Pequenas / Superóxido Dismutase-1 / Esclerose Lateral Amiotrófica / Proteínas de Membrana Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Modelos Animais de Doenças / Bibliotecas de Moléculas Pequenas / Superóxido Dismutase-1 / Esclerose Lateral Amiotrófica / Proteínas de Membrana Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão