Your browser doesn't support javascript.
loading
Specific Features of Transcription Activity of Cancer-Testis Antigens in Patients with Metastatic and Non-Metastatic Breast Cancer.
Vodolazhsky, D I; Kutilin, D S; Mogushkova, Kh A; Kit, O I.
Afiliação
  • Vodolazhsky DI; Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
  • Kutilin DS; Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia. k.denees@yandex.ru.
  • Mogushkova KA; Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
  • Kit OI; Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
Bull Exp Biol Med ; 165(3): 382-385, 2018 Jul.
Article em En | MEDLINE | ID: mdl-30006881
Cancer-testis antigens, effective markers of tissue malignant transformation, are characterized by heterogonous transcription depending on the pathological features of breast cancer. We performed screening of transcription profile of cancer-testis antigens specific for breast tumor tissues in female patients with and without regional metastasis. The relative expression of 16 genes (MAGEA1, MAGEA2, MAGEA3, MAGEA4, MAGEB1, MAGEB2, GAGE1, GAGE3, GAGE4, MAGEC1, BAGE, XAGE3, NY-ESO1, SSX2, SYCP1, and PRAME1) was analyzed by RT-qPCR method in biopsy specimens of the mammary gland tissues obtained during surgery from 25 patients. Differential transcription activity of cancer-testis antigens genes was observed in patients with metastatic (enhanced expression of MAGEA2, MAGEB1, and XAGE3 genes) and non-metastatic (enhanced expression of GAGE3 and PRAME1 genes) breast cancer.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transcrição Gênica / Neoplasias da Mama / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Antígenos de Neoplasias / Proteínas de Neoplasias Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Federação Russa
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transcrição Gênica / Neoplasias da Mama / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Antígenos de Neoplasias / Proteínas de Neoplasias Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Federação Russa