Molecular Actions of PPARα in Lipid Metabolism and Inflammation.
Endocr Rev
; 39(5): 760-802, 2018 10 01.
Article
em En
| MEDLINE
| ID: mdl-30020428
ABSTRACT
Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPARα also exhibits marked anti-inflammatory capacities. The first-generation PPARα agonists, the fibrates, have however been hampered by drug-drug interaction issues, statin drop-in, and ill-designed cardiovascular intervention trials. Notwithstanding, understanding the molecular mechanisms by which PPARα works will enable control of its activities as a drug target for metabolic diseases with an underlying inflammatory component. Given its role in reshaping the immune system, the full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
PPAR alfa
/
Metabolismo dos Lipídeos
/
Inflamação
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Endocr Rev
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Bélgica