[Novel treatment options must prove their effectiveness: targeted treatment and immunotherapy for locally advanced melanoma]. / Uitbreiding behandelarsenaal vraagt om doelmatigheid.
Ned Tijdschr Geneeskd
; 1622018 Jun 15.
Article
em Nl
| MEDLINE
| ID: mdl-30040280
ABSTRACT
The rapidly developing novel therapies for metastatic melanoma (stage IV) are now starting to prove their value in the adjuvant treatment of stage III melanoma. Two studies recently published in The New England Journal of Medicine, the CheckMate 238 study and the Combi-AD study, both show a significantly increased chance of recurrence-free survival for stage III melanoma patients. In the adjuvant setting, immunotherapy by checkpoint inhibition and targeted therapy may therefore become newly available therapeutic options. Pending EMA approval, this may prove to be good news for patients. In the Netherlands, continued critical appraisal of these expensive treatment modalities in metastatic melanoma is mandatory, as issued by the Dutch Government. This important documentation of expensive oncological therapeutics should also be carried out for adjuvant treatments by the expert centres that are experienced in the use and structured evaluation of these therapies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Terapia de Alvo Molecular
/
Fatores Imunológicos
/
Imunoterapia
/
Melanoma
/
Antimetabólitos Antineoplásicos
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
Nl
Revista:
Ned Tijdschr Geneeskd
Ano de publicação:
2018
Tipo de documento:
Article