Five-Year Longitudinal Study of Neck Vessel Cross-Sectional Area in Multiple Sclerosis.
AJNR Am J Neuroradiol
; 39(9): 1703-1709, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30049718
ABSTRACT
BACKGROUND AND PURPOSE:
Alterations of neck vessel cross-sectional area in multiple sclerosis have been reported. Our aim was to investigate the evolution of the neck vessel cross-sectional area in patients with MS and healthy controls during 5 years. MATERIALS ANDMETHODS:
Sixty-nine patients with MS (44 relapsing-remitting MS, 25 progressive MS) and 22 age- and sex-matched healthy controls were examined twice, 5 years apart, on a 3T MR imaging scanner using 2D neck MR angiography. Cross-sectional areas were computed for the common carotid/internal carotid arteries, vertebral arteries, and internal jugular veins for all slices between the C3 and C7 cervical levels. Longitudinal cross-sectional area differences at each cervical level and the whole-vessel course were tested within study groups and between patients with MS with and without cardiovascular disease using mixed-model analysis and the related-samples Wilcoxon singed rank test. The Benjamini-Hochberg procedure was performed to correct for multiple comparisons.RESULTS:
No significant cross-sectional area differences were seen between patients with MS and healthy controls at baseline or at follow-up. During the follow-up, significant cross-sectional area decrease was found in patients with MS for the common carotid artery-ICAs (C4 P = .048; C7 P = .005; whole vessel P = .012), for vertebral arteries (C3 P = .028; C4 P = .028; C7 P = .028; whole vessel P = .012), and for the internal jugular veins (C3 P = .014; C4 P = .008; C5 P = .010; C6 P = .010; C7 P = .008; whole vessel P = .002). Patients with MS without cardiovascular disease had significantly greater change than patients with MS with cardiovascular disease for internal jugular veins at all levels.CONCLUSIONS:
For 5 years, patients with MS showed significant cross-sectional area decrease of all major neck vessels, regardless of the disease course and cardiovascular status.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artéria Vertebral
/
Artérias Carótidas
/
Veias Jugulares
/
Esclerose Múltipla
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
AJNR Am J Neuroradiol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Itália