Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH.

Shin, Sun Hae Ra; McAninch, Patrick T; Henderson, Ian M; Gomez, Andrew; Greene, Adrienne C; Carnes, Eric C; Paxton, Walter F

Shin, Sun Hae Ra; McAninch, Patrick T; Henderson, Ian M; Gomez, Andrew; Greene, Adrienne C; Carnes, Eric C; Paxton, Walter F.

Afiliação

Shin SHR; Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, NM 87185, USA. wfpaxto@sandia.gov.
McAninch PT; Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, NM 87185, USA. wfpaxto@sandia.gov.
Henderson IM; Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, NM 87185, USA. wfpaxto@sandia.gov and Omphalos Bioscience LLC, Albuquerque, NM 87110, USA.
Gomez A; Nano and Micro Sensors, Sandia National Laboratories, Albuquerque, NM 87185, USA.
Greene AC; Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, NM 87185, USA. wfpaxto@sandia.gov.
Carnes EC; Office of Research and Economic Development, University of Nebraska - Lincoln, Lincoln, NE 68588, USA.
Paxton WF; Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, NM 87185, USA. wfpaxto@sandia.gov.

Chem Commun (Camb) ; 54(65): 9043-9046, 2018 Aug 21.

Article em En | MEDLINE | ID: mdl-30051116

ABSTRACT

ABSTRACT

Self-assembled giant polymer vesicles prepared from double-hydrophilic diblock copolymers, poly(ethylene oxide)-b-poly(acrylic acid) (PEO-PAA) show significant degradation in response to pH changes. Because of the switching behavior of the diblock copolymers at biologically-relevant pH environments (2 to 9), these polymer vesicles have potential biomedical applications as smart delivery vehicles.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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