Microvascular Endothelial Function and Neurocognition Among Adults With Major Depressive Disorder.
Am J Geriatr Psychiatry
; 26(10): 1061-1069, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30093218
ABSTRACT
BACKGROUND:
Cardiovascular risk factors (CVRFs) and endothelial dysfunction have been associated independently with poorer neurocognition in middle-aged adults, particularly on tests of frontal lobe function. However, to our knowledge, no studies have examined markers of microvascular dysfunction on neurocognition or the potential interaction between macro- and microvascular biomarkers on neurocognition in middle-aged and older adults with major depressive disorder (MDD).METHODS:
Participants included 202 adults with MDD who were not receiving mental health treatment. Microvascular endothelial function was assessed using a noninvasive marker of forearm reactive hyperemia velocity while macrovascular endothelial function was assessed using flow-mediated dilation (FMD) of the brachial artery. CVRFs were assessed using the Framingham Stroke Risk Profile and fasting lipid levels. A standardized neurocognitive assessment battery was used to assess three cognitive domains executive function, working memory, and verbal memory.RESULTS:
Greater microvascular dysfunction was associated with poorer neurocognition across all three domains. Microvascular function continued to predict verbal memory performance after accounting for background factors and CVRFs. Macro- and microvascular function interacted to predict working memory performance (Fâ¯=â¯4.511, 178, pâ¯=â¯0.035), with a similar nonsignificant association for executive function (Fâ¯=â¯2.731, 178, pâ¯=â¯0.095), with moderate associations observed between microvascular function and neurocognition in the presence of preserved FMD (r61â¯=â¯0.40, pâ¯=â¯0.001), but not when FMD was impaired (r63â¯=â¯-0.05, pâ¯=â¯0.675).CONCLUSION:
Greater microvascular dysfunction is associated with poorer neurocognition among middle-aged and older adults. This association was strongest in participants with preserved macrovascular function.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Vasculares
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Endotélio Vascular
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Transtorno Depressivo Maior
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Microvasos
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Disfunção Cognitiva
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Am J Geriatr Psychiatry
Assunto da revista:
GERIATRIA
/
PSIQUIATRIA
Ano de publicação:
2018
Tipo de documento:
Article