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A Multicenter Case-control Study of the Effect of Acute Rejection and Cytomegalovirus Infection on Pneumocystis Pneumonia in Solid Organ Transplant Recipients.
Hosseini-Moghaddam, S M; Shokoohi, M; Singh, G; Dufresne, S F; Boucher, A; Jevnikar, A; Prasad, G V R; Shoker, A; Kabbani, D; Hebert, M J; Cardinal, H; Houde, I; Humar, A; Kumar, D.
Afiliação
  • Hosseini-Moghaddam SM; Division of Infectious Diseases, Department of Medicine, Schulich School of Medicine and Dentistry, London Health Sciences Centre, London, Ontario.
  • Shokoohi M; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, London, Ontario.
  • Singh G; Multiorgan Transplant Program, London Health Sciences Centre, Western University, London, Ontario.
  • Dufresne SF; Canadian National Transplant Research Program -CNTRP, Québec.
  • Boucher A; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, London, Ontario.
  • Jevnikar A; Multiorgan Transplant Program, London Health Sciences Centre, Western University, London, Ontario.
  • Prasad GVR; Department of Medicine, Maisonneuve-Rosemont Hospital, Québec.
  • Shoker A; Department of Medicine, Maisonneuve-Rosemont Hospital, Québec.
  • Kabbani D; Centre hospitalier de l'Université de Montréal, Université de Montréal, Québec.
  • Hebert MJ; Multiorgan Transplant Program, London Health Sciences Centre, Western University, London, Ontario.
  • Cardinal H; Kidney Transplant Program, St Michael's Hospital, University of Toronto, Ontario.
  • Houde I; Kidney Transplant Program, College of Medicine, University of Saskatchewan, Saskatoon.
  • Humar A; Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton.
  • Kumar D; Canadian National Transplant Research Program -CNTRP, Québec.
Clin Infect Dis ; 68(8): 1320-1326, 2019 04 08.
Article em En | MEDLINE | ID: mdl-30107568
ABSTRACT

BACKGROUND:

Pneumocystis pneumonia (PCP) is associated with morbidity and mortality in solid organ transplant (SOT) recipients. In this case-control study, we determined the association between posttransplant PCP and 3 variables cytomegalovirus (CMV) infection, allograft rejection, and prophylaxis.

METHODS:

Eight transplant centers participated. For each case (SOT recipient with PCP), 3-5 controls (SOT recipients without PCP) were included. Controls were matched to the cases based on transplant center, type of allograft, and date of transplantation (±6 months).

RESULTS:

We enrolled 53 cases and 209 controls. Transplant types included kidney (n = 198), heart (n = 30), liver (n = 15), kidney-pancreas (n = 14), and lung (n = 5). PCP occurred beyond 12 months after transplantation in 43 (81.1%) cases. Thirty-four cases (64.1%) required admission to the intensive care unit, and 28 (52.8%) had mechanical ventilation. Allograft failure occurred in 20 (37.7%) cases, and 14 (26.9%) died. No patient developed PCP prophylaxis breakthrough. The proportion of female sex (P = .009), kidney dysfunction (P = .001), cardiac diseases (P = .005), diabetes mellitus (P = .03), allograft rejection (P = .001), CMV infection (P = .001), and severe lymphopenia (P = .001) were significantly higher in cases. In the logistic regression model, CMV infection (adjusted odds ratio [aOR], 4.6 [95% confidence interval {CI}, 2.0-10.5]) and allograft rejection (aOR, 3.0 [95% CI, 1.5-6.1]) significantly increased the likelihood of PCP.

CONCLUSIONS:

PCP was mostly a late-onset disease occurring after complete course of prophylaxis, particularly among patients with CMV infection or allograft rejection. PCP is associated with significant allograft loss. Extended prophylaxis targeting recipients with allograft rejection or CMV infection may reduce the risk of PCP.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia por Pneumocystis / Infecções por Citomegalovirus / Rejeição de Enxerto Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia por Pneumocystis / Infecções por Citomegalovirus / Rejeição de Enxerto Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2019 Tipo de documento: Article