Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.

Cunningham, Kellie E; Novak, Elizabeth A; Vincent, Garret; Siow, Vei Shaun; Griffith, Brian D; Ranganathan, Sarangarajan; Rosengart, Matthew R; Piganelli, Jon D; Mollen, Kevin P

Cunningham, Kellie E; Novak, Elizabeth A; Vincent, Garret; Siow, Vei Shaun; Griffith, Brian D; Ranganathan, Sarangarajan; Rosengart, Matthew R; Piganelli, Jon D; Mollen, Kevin P.

Afiliação

Cunningham KE; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Novak EA; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Vincent G; Division of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, USA.
Siow VS; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Griffith BD; Division of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, USA.
Ranganathan S; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Rosengart MR; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Piganelli JD; Department of Pathology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, USA.
Mollen KP; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

FASEB J ; 33(1): 1330-1346, 2019 01.

Article em En | MEDLINE | ID: mdl-30113881

Assuntos

Proteína Quinase Tipo 4 Dependente de Cálcio-Calmodulina/metabolismo; Proliferação de Células; Colite/enzimologia; Colite/patologia; Mucosa Intestinal/patologia; Animais; Cálcio/metabolismo; Proteína Quinase Tipo 4 Dependente de Cálcio-Calmodulina/genética; Colite/induzido quimicamente; Colite Ulcerativa/enzimologia; Colite Ulcerativa/metabolismo; Colite Ulcerativa/patologia; Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo; Sulfato de Dextrana/toxicidade; Ativação Enzimática; Humanos; Mucosa Intestinal/enzimologia; Camundongos; Camundongos Knockout; Transdução de Sinais

Palavras-chave

CREB; inflammatory bowel disease; intestinal epithelial barrier; intracellular calcium signaling

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite / Proliferação de Células / Proteína Quinase Tipo 4 Dependente de Cálcio-Calmodulina / Mucosa Intestinal Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google