Additional evidence for a therapeutic effect of dextromethorphan/quinidine on bulbar motor function in patients with amyotrophic lateral sclerosis: A quantitative speech analysis.

Green, Jordan R; Allison, Kristen M; Cordella, Claire; Richburg, Brian D; Pattee, Gary L; Berry, James D; Macklin, Eric A; Pioro, Erik P; Smith, Richard A

Green, Jordan R; Allison, Kristen M; Cordella, Claire; Richburg, Brian D; Pattee, Gary L; Berry, James D; Macklin, Eric A; Pioro, Erik P; Smith, Richard A.

Afiliação

Green JR; Speech and Feeding Disorders Lab, MGH Institute of Health Professions, Charlestown, MA, USA.
Allison KM; Program in Speech and Hearing Bioscience and Technology Program, Division of Medical Sciences, Harvard University, Boston, MA, USA.
Cordella C; Speech and Feeding Disorders Lab, MGH Institute of Health Professions, Charlestown, MA, USA.
Richburg BD; Department of Communication Sciences and Disorders, Bouve College of Health Sciences, Northeastern University, Boston, MA, USA.
Pattee GL; Speech and Feeding Disorders Lab, MGH Institute of Health Professions, Charlestown, MA, USA.
Berry JD; Program in Speech and Hearing Bioscience and Technology Program, Division of Medical Sciences, Harvard University, Boston, MA, USA.
Macklin EA; Speech and Feeding Disorders Lab, MGH Institute of Health Professions, Charlestown, MA, USA.
Pioro EP; Department of Neurology, University of Nebraska Medical College, Omaha, NE, USA.
Smith RA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Br J Clin Pharmacol ; 84(12): 2849-2856, 2018 12.

Article em En | MEDLINE | ID: mdl-30152872

Assuntos

Esclerose Lateral Amiotrófica/tratamento farmacológico; Dextrometorfano/uso terapêutico; Quinidina/uso terapêutico; Fala/efeitos dos fármacos; Adulto; Idoso; Esclerose Lateral Amiotrófica/fisiopatologia; Esclerose Lateral Amiotrófica/psicologia; Combinação de Medicamentos; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Avaliação de Resultados em Cuidados de Saúde

Palavras-chave

amyotrophic lateral sclerosis; bulbar function; combination; dextromethorphan; dysarthria; quinidine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinidina / Fala / Dextrometorfano / Esclerose Lateral Amiotrófica Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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