Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a "dominant-positive" mechanism.

Walerych, Dawid; Pruszko, Magdalena; Zyla, Lukasz; Wezyk, Michalina; Gaweda-Walerych, Katarzyna; Zylicz, Alicja

Walerych, Dawid; Pruszko, Magdalena; Zyla, Lukasz; Wezyk, Michalina; Gaweda-Walerych, Katarzyna; Zylicz, Alicja.

Afiliação

Walerych D; Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Pruszko M; Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Zyla L; International Institute of Molecular and Cell Biology in Warsaw, 02-109 Warsaw, Poland.
Wezyk M; Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Gaweda-Walerych K; Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Zylicz A; International Institute of Molecular and Cell Biology in Warsaw, 02-109 Warsaw, Poland.

Oncotarget ; 9(62): 32063-32080, 2018 Aug 10.

Article em En | MEDLINE | ID: mdl-30174797

Palavras-chave

FRET; dominant-negative; gain-of-function; oligomerization; p53

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Oncotarget Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Polônia

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