Synthesis of 2,2-Dialkyl Chromanes by Intramolecular Ullmann C-O Coupling Reactions toward the Total Synthesis of D-α-Tocopherol.
Chem Pharm Bull (Tokyo)
; 66(9): 843-846, 2018.
Article
em En
| MEDLINE
| ID: mdl-30175739
ABSTRACT
The complete synthesis of D-α-tocopherol was achieved using our developed-Ullmann C-O coupling reaction as a key reaction. The synthesis of the core structure of D-α-tocopherol, which is a chiral chromane, has never been reported using intramolecular Ullmann C-O coupling reactions owing to the low reactivity of electron-rich iodoarenes with tertiary alcohols. Because the developed intramolecular C-O coupling reactions prefer electron-rich iodoarenes with tertiary alcohols, we successfully synthesized the chiral chromane core and achieved the total synthesis of D-α-tocopherol.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromanos
/
Alfa-Tocoferol
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Ano de publicação:
2018
Tipo de documento:
Article