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Precancerous neoplastic cells can move through the pancreatic ductal system.
Makohon-Moore, Alvin P; Matsukuma, Karen; Zhang, Ming; Reiter, Johannes G; Gerold, Jeffrey M; Jiao, Yuchen; Sikkema, Lisa; Attiyeh, Marc A; Yachida, Shinichi; Sandone, Corinne; Hruban, Ralph H; Klimstra, David S; Papadopoulos, Nickolas; Nowak, Martin A; Kinzler, Kenneth W; Vogelstein, Bert; Iacobuzio-Donahue, Christine A.
Afiliação
  • Makohon-Moore AP; The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Matsukuma K; Department of Pathology, University of California, Davis, Sacramento, CA, USA.
  • Zhang M; The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Reiter JG; Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, USA.
  • Gerold JM; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA, USA.
  • Jiao Y; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA, USA.
  • Sikkema L; The Ludwig Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Attiyeh MA; The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Yachida S; VU University Amsterdam, Master's Oncology Program, VU University Medical Center, Amsterdam, The Netherlands.
  • Sandone C; The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Hruban RH; Department of Cancer Genome Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.
  • Klimstra DS; Department of Art as Applied to Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Papadopoulos N; The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Nowak MA; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Kinzler KW; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Vogelstein B; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Iacobuzio-Donahue CA; The Ludwig Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nature ; 561(7722): 201-205, 2018 09.
Article em En | MEDLINE | ID: mdl-30177826
ABSTRACT
Most adult carcinomas develop from noninvasive precursor lesions, a progression that is supported by genetic analysis. However, the evolutionary and genetic relationships among co-existing lesions are unclear. Here we analysed the somatic variants of pancreatic cancers and precursor lesions sampled from distinct regions of the same pancreas. After inferring evolutionary relationships, we found that the ancestral cell had initiated and clonally expanded to form one or more lesions, and that subsequent driver gene mutations eventually led to invasive pancreatic cancer. We estimate that this multi-step progression generally spans many years. These new data reframe the step-wise progression model of pancreatic cancer by illustrating that independent, high-grade pancreatic precursor lesions observed in a single pancreas often represent a single neoplasm that has colonized the ductal system, accumulating spatial and genetic divergence over time.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ductos Pancreáticos / Lesões Pré-Cancerosas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nature Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ductos Pancreáticos / Lesões Pré-Cancerosas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nature Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos