Your browser doesn't support javascript.
loading
An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis.
Roediger, Ben; Lee, Quintin; Tikoo, Shweta; Cobbin, Joanna C A; Henderson, James M; Jormakka, Mika; O'Rourke, Matthew B; Padula, Matthew P; Pinello, Natalia; Henry, Marisa; Wynne, Maria; Santagostino, Sara F; Brayton, Cory F; Rasmussen, Lorna; Lisowski, Leszek; Tay, Szun S; Harris, David C; Bertram, John F; Dowling, John P; Bertolino, Patrick; Lai, Jack H; Wu, Wengen; Bachovchin, William W; Wong, Justin J-L; Gorrell, Mark D; Shaban, Babak; Holmes, Edward C; Jolly, Christopher J; Monette, Sébastien; Weninger, Wolfgang.
Afiliação
  • Roediger B; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia. Electronic address: b.roediger@centenary.org.au.
  • Lee Q; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
  • Tikoo S; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
  • Cobbin JCA; Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
  • Henderson JM; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
  • Jormakka M; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
  • O'Rourke MB; Mass Spectrometry Core Facility, University of Sydney, Sydney, NSW 2006, Australia; Proteomics Core Facility, University of Technology Sydney, Ultimo, NSW 2007, Australia.
  • Padula MP; Proteomics Core Facility, University of Technology Sydney, Ultimo, NSW 2007, Australia.
  • Pinello N; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
  • Henry M; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia; Laboratory Animal Services, University of Sydney, Sydney, NSW 2006, Australia.
  • Wynne M; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia; Laboratory Animal Services, University of Sydney, Sydney, NSW 2006, Australia.
  • Santagostino SF; Laboratory of Comparative Pathology, Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY 10065, USA.
  • Brayton CF; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Rasmussen L; Cerberus Sciences, Thebarton, SA 5031, Australia.
  • Lisowski L; Children's Medical Research Institute, University of Sydney, Sydney, NSW 2006, Australia; Military Institute of Hygiene and Epidemiology, Biological Threats Identification and Countermeasure Centre, Pulawy 24-100, Poland.
  • Tay SS; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
  • Harris DC; Centre for Transplantation and Renal Research, Westmead Institute for Medical Research, University of Sydney, NSW 2006, Australia.
  • Bertram JF; Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia.
  • Dowling JP; Department of Anatomical Pathology, Monash Medical Centre, Clayton, VIC 3168, Australia.
  • Bertolino P; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
  • Lai JH; Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
  • Wu W; Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
  • Bachovchin WW; Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
  • Wong JJ; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
  • Gorrell MD; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
  • Shaban B; Australian Genomics Research Facility, Parkville, VIC 3000, Australia; Melbourne Integrative Genomics, University of Melbourne, Parkville, VIC 3010, Australia.
  • Holmes EC; Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
  • Jolly CJ; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
  • Monette S; Laboratory of Comparative Pathology, Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY 10065, USA.
  • Weninger W; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia; Discipline of Dermatology, Faculty of Medicine and Health, University of Sydney, NSW 2006, Australia; Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Austral
Cell ; 175(2): 530-543.e24, 2018 10 04.
Article em En | MEDLINE | ID: mdl-30220458
ABSTRACT
The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed "mouse kidney parvovirus" (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parvovirus / Nefrite Intersticial Limite: Animals / Female / Humans / Male País/Região como assunto: America do norte / Oceania Idioma: En Revista: Cell Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parvovirus / Nefrite Intersticial Limite: Animals / Female / Humans / Male País/Região como assunto: America do norte / Oceania Idioma: En Revista: Cell Ano de publicação: 2018 Tipo de documento: Article