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An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity.
Liang, Jia-Hao; Huo, Xiao-Kui; Cheng, Zhong-Bin; Sun, Cheng-Peng; Zhao, Jian-Chao; Kang, Xiao-Hui; Zhang, Tian-Yuan; Chen, Zhong-Jian; Yang, Tian-Mei; Wu, Ying-Ying; Deng, Xiao-Peng; Zhang, Yi-Xuan.
Afiliação
  • Liang JH; a College of Pharmacy, College (Institute) of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical University , Dalian , China.
  • Huo XK; b School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University , Shenyang , China.
  • Cheng ZB; a College of Pharmacy, College (Institute) of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical University , Dalian , China.
  • Sun CP; c Pharmaceutical College, Henan University , Kaifeng , China.
  • Zhao JC; a College of Pharmacy, College (Institute) of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical University , Dalian , China.
  • Kang XH; b School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University , Shenyang , China.
  • Zhang TY; a College of Pharmacy, College (Institute) of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical University , Dalian , China.
  • Chen ZJ; b School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University , Shenyang , China.
  • Yang TM; d Wenshan Sanqi Research Institute, Wenshan University , Wenshan , China.
  • Wu YY; e Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences , Kunming , China.
  • Deng XP; b School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University , Shenyang , China.
  • Zhang YX; f Dalian Maternal and Child Care Health Hospital , Dalian , China.
Nat Prod Res ; 33(19): 2770-2776, 2019 Oct.
Article em En | MEDLINE | ID: mdl-30221546
ABSTRACT
One new indole diterpenoid, drechmerin I (1), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1) was assayed for its antimicrobial activity against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin I (1) showed antimicrobial activities against B. subtillis with an MIC value of 200 µg/mL. The interaction of S. aureus peptide deformylase with drechmerin I (1) was investigated by molecular docking.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides Indólicos / Alcaloides Diterpenos / Hypocreales / Anti-Infecciosos Idioma: En Revista: Nat Prod Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides Indólicos / Alcaloides Diterpenos / Hypocreales / Anti-Infecciosos Idioma: En Revista: Nat Prod Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China