The Multiple Levels of Mitonuclear Coregulation.
Annu Rev Genet
; 52: 511-533, 2018 11 23.
Article
em En
| MEDLINE
| ID: mdl-30230928
ABSTRACT
Together, the nuclear and mitochondrial genomes encode the oxidative phosphorylation (OXPHOS) complexes that reside in the mitochondrial inner membrane and enable aerobic life. Mitochondria maintain their own genome that is expressed and regulated by factors distinct from their nuclear counterparts. For optimal function, the cell must ensure proper stoichiometric production of OXPHOS subunits by coordinating two physically separated and evolutionarily distinct gene expression systems. Here, we review our current understanding of mitonuclear coregulation primarily at the levels of transcription and translation. Additionally, we discuss other levels of coregulation that may exist but remain largely unexplored, including mRNA modification and stability and posttranslational protein degradation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosforilação Oxidativa
/
Genoma
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Evolução Biológica
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Genoma Mitocondrial
Idioma:
En
Revista:
Annu Rev Genet
Ano de publicação:
2018
Tipo de documento:
Article