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Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria.
Urquiza, Pedro; Laín, Ana; Sanz-Parra, Arantza; Moreno, Jorge; Bernardo-Seisdedos, Ganeko; Dubus, Pierre; González, Esperanza; Gutiérrez-de-Juan, Virginia; García, Sandra; Eraña, Hasier; San Juan, Itxaso; Macías, Iratxe; Ben Bdira, Fredj; Pluta, Paula; Ortega, Gabriel; Oyarzábal, Julen; González-Muñiz, Rosario; Rodríguez-Cuesta, Juan; Anguita, Juan; Díez, Emilio; Blouin, Jean-Marc; de Verneuil, Hubert; Mato, José M; Richard, Emmanuel; Falcón-Pérez, Juan M; Castilla, Joaquín; Millet, Oscar.
Afiliação
  • Urquiza P; Protein Stability and Inherited Disease Laboratory, CIC bioGUNE, 48160 Derio, Spain.
  • Laín A; Protein Stability and Inherited Disease Laboratory, CIC bioGUNE, 48160 Derio, Spain.
  • Sanz-Parra A; Protein Stability and Inherited Disease Laboratory, CIC bioGUNE, 48160 Derio, Spain.
  • Moreno J; Prion Research Laboratory, CIC bioGUNE, 48160 Derio, Spain.
  • Bernardo-Seisdedos G; Atlas Molecular Pharma S. L., 48160 Derio, Spain.
  • Dubus P; Univerité de Bordeaux, Bordeaux Research in Translational Oncology, INSERM U1053, F-33000 Bordeaux, France.
  • González E; INSERM, Biothérapie des Maladies Génétiques, Inflammatoires et Cancers, U1035, Bordeaux, France.
  • Gutiérrez-de-Juan V; Exosomes Laboratory, CIC bioGUNE, 48160 Derio, Spain.
  • García S; Liver Metabolism Laboratory, CIC bioGUNE, 48160 Derio, Spain.
  • Eraña H; Atlas Molecular Pharma S. L., 48160 Derio, Spain.
  • San Juan I; Atlas Molecular Pharma S. L., 48160 Derio, Spain.
  • Macías I; Protein Stability and Inherited Disease Laboratory, CIC bioGUNE, 48160 Derio, Spain.
  • Ben Bdira F; Protein Stability and Inherited Disease Laboratory, CIC bioGUNE, 48160 Derio, Spain.
  • Pluta P; Protein Stability and Inherited Disease Laboratory, CIC bioGUNE, 48160 Derio, Spain.
  • Ortega G; Department of Macromolecular Biochemistry, Leiden Institute of Chemistry, 2300 RA Leiden, Netherlands.
  • Oyarzábal J; Protein Stability and Inherited Disease Laboratory, CIC bioGUNE, 48160 Derio, Spain.
  • González-Muñiz R; Protein Stability and Inherited Disease Laboratory, CIC bioGUNE, 48160 Derio, Spain.
  • Rodríguez-Cuesta J; Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA 93106-9510, USA.
  • Anguita J; Small Molecule Discovery Platform, Center for Applied Medical Research, University of Navarra, 31008 Pamplona, Spain.
  • Díez E; Instituto de Química Médica, IQM-CSIC, 28006 Madrid, Spain.
  • Blouin JM; Animal Facility, CIC bioGUNE, 48160 Derio, Spain.
  • de Verneuil H; Animal Facility, CIC bioGUNE, 48160 Derio, Spain.
  • Mato JM; Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain.
  • Richard E; Macrophage and Tick Vaccine Laboratory, CIC bioGUNE, 48160 Derio, Spain.
  • Falcón-Pérez JM; Atlas Molecular Pharma S. L., 48160 Derio, Spain.
  • Castilla J; Université de Bordeaux, Biothérapie des Maladies Génétiques, Inflammatoires et Cancers, U1035, F-33000 Bordeaux, France.
  • Millet O; Université de Bordeaux, Biothérapie des Maladies Génétiques, Inflammatoires et Cancers, U1035, F-33000 Bordeaux, France.
Sci Transl Med ; 10(459)2018 09 19.
Article em En | MEDLINE | ID: mdl-30232228
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Porfiria Eritropoética / Reposicionamento de Medicamentos / Ciclopirox Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Espanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Porfiria Eritropoética / Reposicionamento de Medicamentos / Ciclopirox Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Espanha