Short-term and long-term human or mouse organoid units generate tissue-engineered small intestine without added signalling molecules.

Hou, Xiaogang; Chang, David F; Trecartin, Andrew; Barthel, Erik R; Schlieve, Christopher R; Frey, Mark R; Fowler, Kathryn L; Grikscheit, Tracy C

Hou, Xiaogang; Chang, David F; Trecartin, Andrew; Barthel, Erik R; Schlieve, Christopher R; Frey, Mark R; Fowler, Kathryn L; Grikscheit, Tracy C.

Afiliação

Hou X; Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Chang DF; Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Trecartin A; Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Barthel ER; Division of Pediatric Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Schlieve CR; Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Frey MR; Division of Pediatric Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Fowler KL; Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Grikscheit TC; Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Exp Physiol ; 103(12): 1633-1644, 2018 12.

Article em En | MEDLINE | ID: mdl-30232817

Assuntos

Intestino Delgado/metabolismo; Organoides/metabolismo; Animais; Proliferação de Células/fisiologia; Sistema Nervoso Entérico/metabolismo; Células Epiteliais/metabolismo; Humanos; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Mucosa Intestinal/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos NOD; Camundongos SCID; Engenharia Tecidual/métodos

Palavras-chave

enteroids; intestinal stem cells; organoid units; tissue-engineered small intestine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Organoides / Intestino Delgado Limite: Animals / Humans Idioma: En Revista: Exp Physiol Assunto da revista: FISIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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