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The possible modulation of morphine analgesia by the supramolecular GABA receptor complex.
Psychopharmacology (Berl) ; 90(2): 244-6, 1986.
Article em En | MEDLINE | ID: mdl-3024198
In the present study, the mechanism of the antagonistic action of 0.5 mg/kg diazepam on the analgesic effect of morphine was investigated. While Ro 15-1788, a benzodiazepine receptor antagonist, was found to partially reverse the inhibitory action of diazepam on morphine analgesia, a chloride channel blocking agent, picrotoxin, produced complete antagonism of the action of diazepam. Furthermore, picrotoxin potentiated the partial antagonistic effect of Ro 15-1788 at a normally ineffective dose to affect the 0.5 mg/kg diazepam-morphine dose-response curve. These overall effects of picrotoxin on the supramolecular GABA receptor complex are discussed.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de GABA-A / Analgésicos / Morfina Limite: Animals Idioma: En Revista: Psychopharmacology (Berl) Ano de publicação: 1986 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de GABA-A / Analgésicos / Morfina Limite: Animals Idioma: En Revista: Psychopharmacology (Berl) Ano de publicação: 1986 Tipo de documento: Article