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Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1.
Lu, Mei-Hong; Ji, Wen-Li; Xu, De-En; Yao, Pei-Pei; Zhao, Xiu-Yun; Wang, Zhao-Tao; Fang, Li-Pao; Huang, Rui; Lan, Li-Jun; Chen, Ji-Bo; Wang, Ting-Hua; Cheng, Li-Hua; Xu, Ru-Xiang; Liu, Chun-Feng; Puglielli, Luigi; Ma, Quan-Hong.
Afiliação
  • Lu MH; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho- Diseases, Institute of Neuroscience, Soochow University, Suzhou 215004, China; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suz
  • Ji WL; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho- Diseases, Institute of Neuroscience, Soochow University, Suzhou 215004, China; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suz
  • Xu DE; Department of Neurology, The Second People's Hospital of Wuxi, Wuxi 214002, China.
  • Yao PP; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho- Diseases, Institute of Neuroscience, Soochow University, Suzhou 215004, China; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suz
  • Zhao XY; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho- Diseases, Institute of Neuroscience, Soochow University, Suzhou 215004, China; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suz
  • Wang ZT; Affiliated Bayi Brain Hospital, Military General Hospital of Beijing PLA, Southern Medical University, Beijing 100700, China.
  • Fang LP; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho- Diseases, Institute of Neuroscience, Soochow University, Suzhou 215004, China; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suz
  • Huang R; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho- Diseases, Institute of Neuroscience, Soochow University, Suzhou 215004, China; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suz
  • Lan LJ; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho- Diseases, Institute of Neuroscience, Soochow University, Suzhou 215004, China; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suz
  • Chen JB; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho- Diseases, Institute of Neuroscience, Soochow University, Suzhou 215004, China; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suz
  • Wang TH; Institute of Neuroscience, Kunming Medical University, Kunming 650500, China.
  • Cheng LH; Affiliated Bayi Brain Hospital, Military General Hospital of Beijing PLA, Southern Medical University, Beijing 100700, China.
  • Xu RX; Affiliated Bayi Brain Hospital, Military General Hospital of Beijing PLA, Southern Medical University, Beijing 100700, China.
  • Liu CF; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho- Diseases, Institute of Neuroscience, Soochow University, Suzhou 215004, China; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suz
  • Puglielli L; Department of Medicine and Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
  • Ma QH; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho- Diseases, Institute of Neuroscience, Soochow University, Suzhou 215004, China; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suz
Exp Neurol ; 311: 67-79, 2019 01.
Article em En | MEDLINE | ID: mdl-30243987
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Aspártico Endopeptidases / Precursor de Proteína beta-Amiloide / Transferases (Outros Grupos de Fosfato Substituídos) / Secretases da Proteína Precursora do Amiloide / Presenilina-1 / Doença de Alzheimer / Lisossomos Limite: Animals / Humans Idioma: En Revista: Exp Neurol Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Aspártico Endopeptidases / Precursor de Proteína beta-Amiloide / Transferases (Outros Grupos de Fosfato Substituídos) / Secretases da Proteína Precursora do Amiloide / Presenilina-1 / Doença de Alzheimer / Lisossomos Limite: Animals / Humans Idioma: En Revista: Exp Neurol Ano de publicação: 2019 Tipo de documento: Article