Clonal evolution through genetic bottlenecks and telomere attrition: Potential threats to in vitro data reproducibility.

Gisselsson, David; Lichtenzstejn, Daniel; Kachko, Polina; Karlsson, Jenny; Manor, Esther; Mai, Sabine

Gisselsson, David; Lichtenzstejn, Daniel; Kachko, Polina; Karlsson, Jenny; Manor, Esther; Mai, Sabine.

Afiliação

Gisselsson D; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Lichtenzstejn D; Division of Oncology-Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Kachko P; Cell Biology, Research Institute of Oncology and Hematology, The Genomic Centre for Cancer Research and Diagnosis, CancerCare Manitoba, University of Manitoba, Winnipeg, Canada.
Karlsson J; Shraga Segal Department of Microbiology, Immunology and Genetics, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Manor E; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Mai S; Shraga Segal Department of Microbiology, Immunology and Genetics, Ben Gurion University of the Negev, Beer-Sheva, Israel.

Genes Chromosomes Cancer ; 58(7): 452-461, 2019 07.

Article em En | MEDLINE | ID: mdl-30255964

Assuntos

Pesquisa Biomédica/normas; Evolução Clonal/genética; Modelos Genéticos; Telômero/genética; Linhagem Celular Tumoral; Humanos; Mutação/genética; Neoplasias/genética; Neoplasias/patologia; Oncogenes/genética; Erro Científico Experimental; Inoculações Seriadas; Telômero/patologia

Palavras-chave

cancer; cell lines; clonal evolution; genetic bottleneck; telomeres

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Telômero / Pesquisa Biomédica / Evolução Clonal / Modelos Genéticos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Genes Chromosomes Cancer Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suécia

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