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BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
Nacson, Joseph; Krais, John J; Bernhardy, Andrea J; Clausen, Emma; Feng, Wanjuan; Wang, Yifan; Nicolas, Emmanuelle; Cai, Kathy Q; Tricarico, Rossella; Hua, Xiang; DiMarcantonio, Daniela; Martinez, Esteban; Zong, Dali; Handorf, Elizabeth A; Bellacosa, Alfonso; Testa, Joseph R; Nussenzweig, Andre; Gupta, Gaorav P; Sykes, Stephen M; Johnson, Neil.
Afiliação
  • Nacson J; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA; Temple University, Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.
  • Krais JJ; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Bernhardy AJ; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Clausen E; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Feng W; Department of Radiation Oncology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Wang Y; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Nicolas E; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA; Genomics Facility, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Cai KQ; Histopathology Facility, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Tricarico R; Cancer Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Hua X; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • DiMarcantonio D; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Martinez E; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Zong D; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Handorf EA; Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Bellacosa A; Cancer Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Testa JR; Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Gupta GP; Department of Radiation Oncology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Sykes SM; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Johnson N; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address: neil.johnson@fccc.edu.
Cell Rep ; 24(13): 3513-3527.e7, 2018 09 25.
Article em En | MEDLINE | ID: mdl-30257212

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Proteína BRCA1 / Recombinação Homóloga / Inibidores de Poli(ADP-Ribose) Polimerases / Proteína 1 de Ligação à Proteína Supressora de Tumor p53 / Neoplasias Mamárias Experimentais Limite: Animals / Female / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Proteína BRCA1 / Recombinação Homóloga / Inibidores de Poli(ADP-Ribose) Polimerases / Proteína 1 de Ligação à Proteína Supressora de Tumor p53 / Neoplasias Mamárias Experimentais Limite: Animals / Female / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos