Dithiocarbamates: Efficient metallo-ß-lactamase inhibitors with good antibacterial activity when combined with meropenem.

Wang, Ming-Ming; Chu, Wen-Chao; Yang, Yi; Yang, Qian-Qian; Qin, Shang-Shang; Zhang, En

Wang, Ming-Ming; Chu, Wen-Chao; Yang, Yi; Yang, Qian-Qian; Qin, Shang-Shang; Zhang, En.

Afiliação

Wang MM; School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China.
Chu WC; School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China.
Yang Y; School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China.
Yang QQ; School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China.
Qin SS; School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Pr
Zhang E; School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Pr

Bioorg Med Chem Lett ; 28(21): 3436-3440, 2018 11 15.

Article em En | MEDLINE | ID: mdl-30262427

Assuntos

Antibacterianos/farmacologia; Meropeném/farmacologia; Tiocarbamatos/farmacologia; Inibidores de beta-Lactamases/farmacologia; Antibacterianos/síntese química; Antibacterianos/toxicidade; Enterobacteriaceae/efeitos dos fármacos; Eritrócitos/efeitos dos fármacos; Células HeLa; Hemólise/efeitos dos fármacos; Humanos; Testes de Sensibilidade Microbiana; Tiocarbamatos/síntese química; Tiocarbamatos/toxicidade; Zinco/metabolismo; Inibidores de beta-Lactamases/síntese química; Inibidores de beta-Lactamases/toxicidade; beta-Lactamases/metabolismo

Palavras-chave

Antibacterial activity; Antibiotic resistance; Dithiocarbamates; Meropenem; Metallo-ß-lactamase inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiocarbamatos / Inibidores de beta-Lactamases / Meropeném / Antibacterianos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article

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