Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana.

Osei, Musah; Ansah, Felix; Matrevi, Sena A; Asante, Kwaku P; Awandare, Gordon A; Quashie, Neils B; Duah, Nancy O

Osei, Musah; Ansah, Felix; Matrevi, Sena A; Asante, Kwaku P; Awandare, Gordon A; Quashie, Neils B; Duah, Nancy O.

Afiliação

Osei M; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, School of Biological Sciences, College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Ansah F; Kintampo Health Research Centre, Kintampo, Ghana.
Matrevi SA; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, School of Biological Sciences, College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Asante KP; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, School of Biological Sciences, College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Awandare GA; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.
Quashie NB; Kintampo Health Research Centre, Kintampo, Ghana.
Duah NO; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, School of Biological Sciences, College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.

PLoS One ; 13(9): e0204871, 2018.

Article em En | MEDLINE | ID: mdl-30265714

Assuntos

Di-Hidropteroato Sintase/genética; Resistência a Medicamentos/genética; GTP Cicloidrolase/genética; Mutação; Plasmodium falciparum/genética; Proteínas de Protozoários/genética; Tetra-Hidrofolato Desidrogenase/genética; Combinação de Medicamentos; Feminino; Gana; Humanos; Masculino; Plasmodium falciparum/enzimologia; Reação em Cadeia da Polimerase; Pirimetamina; Sulfadoxina

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Tetra-Hidrofolato Desidrogenase / Resistência a Medicamentos / Proteínas de Protozoários / Di-Hidropteroato Sintase / GTP Cicloidrolase / Mutação Limite: Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Gana

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