Locally optimal designs for some binary dose-response models.

ABSTRACT

In this paper, we consider the problem of seeking locally optimal designs for nonlinear dose-response models with binary outcomes. Applying the theory of Tchebycheff Systems and other algebraic tools, we show that the locally D-, A-, and c-optimal designs for three binary dose-response models are minimally supported in finite, closed design intervals. The methods to obtain such designs are presented along with examples. The efficiencies of these designs are also discussed.